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Article

Understanding of the activity of a protein involved in DNA repair by biochemical, structural and <i>in silico</i> approaches

2017-01-03

Abstract excerpt

The repair of DNA from alkylation damage is generally performed by evolutionary conserved protein complexes. However, specific repair of O 6 -alkylated-guanines is a task of a small class of proteins called AGTs (alkylated DNA-protein alkyl-transferases): by using a single-step reaction mechanism, the alkylic group is irreversibly transferred to a catalytic cysteine in the active site, inducing the in vitro and...

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Identifiers and source

Literature Corpus work
66032419-46a4-56b2-9871-44da463e04d7
DOI
10.7287/peerj.preprints.2683v1
Open publication

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Understanding of the activity of a protein involved in DNA repair by biochemical, structural and <i>in silico</i> approachesDOI 10.7287/peerj.preprints.2683v1
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