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Article

Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylase.

Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2009

Lee Seongmin, Verdine Gregory L

Abstract excerpt

Adenine DNA glycosylase catalyzes the glycolytic removal of adenine from the promutagenic A.oxoG base pair in DNA. The general features of DNA recognition by an adenine DNA glycosylase, Bacillus stearothermophilus MutY, have previously been revealed via the X-ray structure of a catalytically inactive mutant protein bound to an A:oxoG-containing DNA duplex. Although the structure revealed the substrate adenine to...

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Identifiers

PMID: 19841264
DOI: 10.1073/pnas.0902908106
PMCID: PMC2773975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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