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Article

The structural basis for the mutagenicity of O(6)-methyl-guanine lesions.

Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2006

Warren Joshua J, Forsberg Lawrence J, Beese Lorena S

Abstract excerpt

Methylating agents are widespread environmental carcinogens that generate a broad spectrum of DNA damage. Methylation at the guanine O(6) position confers the greatest mutagenic and carcinogenic potential. DNA polymerases insert cytosine and thymine with similar efficiency opposite O(6)-methyl-guanine (O6MeG). We combined pre-steady-state kinetic analysis and a series of nine x-ray crystal structures to contrast...

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Identifiers

PMID: 17179038
DOI: 10.1073/pnas.0609580103
PMCID: PMC1750904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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