Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Computational analysis of the mode of binding of 8-oxoguanine to formamidopyrimidine-DNA glycosylase.

Biochemistry - 12 Sept 2006

Song Kun, Hornak Viktor, de Los Santos Carlos, Grollman Arthur P, Simmerling Carlos

Abstract excerpt

8-Oxoguanine (8OG) is the most prevalent form of oxidative DNA damage. In bacteria, 8OG is excised by formamidopyrimidine glycosylase (Fpg) as the initial step in base excision repair. To efficiently excise this lesion, Fpg must discriminate between 8OG and an excess of guanine in duplex DNA. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Computer Simulation
Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Formamidopyrimidine Glycosylase

Share to DNA Repair

Share to Geobacillus stearothermophilus

Share to Guanine

Share to Protein Conformation

Source

Open in PubMed Open full text

Identifiers

PMID: 16953574
DOI: 10.1021/bi060380m
PMCID: PMC8295719

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16953574-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Computational analysis of the mode of binding of 8-oxoguanine to formamidopyrimidine-DNA glycosylase.PMID 16953574Read ↗

A dynamic checkpoint in oxidative lesion discrimination by formamidopyrimidine-DNA glycosylase.Semantic proximity Read ↗

Functional flexibility of Bacillus stearothermophilus formamidopyrimidine DNA-glycosylase.Semantic proximity Read ↗

8-oxoguanine DNA glycosylases: one lesion, three subfamilies.Semantic proximity Read ↗

Mutagenesis mechanism of the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine.Semantic proximity Read ↗

Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA.Semantic proximity Read ↗

The structural basis for the mutagenicity of O(6)-methyl-guanine lesions.Semantic proximity Read ↗

Active destabilization of base pairs by a DNA glycosylase wedge initiates damage recognition.Semantic proximity Read ↗

Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme.Semantic proximity Read ↗

Structural and biochemical analysis of DNA helix invasion by the bacterial 8-oxoguanine DNA glycosylase MutM.Semantic proximity Read ↗

Structure of formamidopyrimidine-DNA glycosylase covalently complexed to DNA.Semantic proximity Read ↗

Distinctive Formation of a DNA-Protein Cross-Link during the Repair of DNA Oxidative Damage: Insights into Human Disease from MD Simulations and QM/MM Calculations.Semantic proximity Read ↗

Molecular mechanisms associated with clustered lesion-induced impairment of 8-oxoG recognition by the human glycosylase OGG1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.