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Article

Computational analysis of the mode of binding of 8-oxoguanine to formamidopyrimidine-DNA glycosylase.

Biochemistry - 12 Sept 2006

Song Kun, Hornak Viktor, de Los Santos Carlos, Grollman Arthur P, Simmerling Carlos

Abstract excerpt

8-Oxoguanine (8OG) is the most prevalent form of oxidative DNA damage. In bacteria, 8OG is excised by formamidopyrimidine glycosylase (Fpg) as the initial step in base excision repair. To efficiently excise this lesion, Fpg must discriminate between 8OG and an excess of guanine in duplex DNA. In this study, we explore the structural basis underlying this high degree of selectivity. Two structures have been...

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Identifiers

PMID: 16953574
DOI: 10.1021/bi060380m
PMCID: PMC8295719

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Source receipt: pubmed, retrieved 7 Sept 2026.

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