Article
HPRT gene expression differs in mutants derived from normal and Fanconi anemia cells: analysis of spontaneous and psoralen-photoinduced mutants.
Somatic cell and molecular genetics - 1 Nov 1991
Guillouf C, Moustacchi E, Papadopoulo D
Abstract excerpt
Fanconi anemia (FA) is an autosomal recessive disorder characterized by chromosomal instability and abnormalities in the processing of DNA lesions induced by cross-linking agents. We previously reported that after photoaddition of psoralen derivatives the frequency of HPRT- mutants was significan...
Topics
- Blotting, Northern
- Cell Line
- Fanconi Anemia
- Furocoumarins
- Gene Expression
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Light
- Mutagenesis
- Mutation
- Nucleic Acid Hybridization
- Polymorphism, Restriction Fragment Length