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Article

HPRT gene expression differs in mutants derived from normal and Fanconi anemia cells: analysis of spontaneous and psoralen-photoinduced mutants.

Somatic cell and molecular genetics - 1 Nov 1991

Guillouf C, Moustacchi E, Papadopoulo D

Abstract excerpt

Fanconi anemia (FA) is an autosomal recessive disorder characterized by chromosomal instability and abnormalities in the processing of DNA lesions induced by cross-linking agents. We previously reported that after photoaddition of psoralen derivatives the frequency of HPRT- mutants was significantly lower in FA than in normal human lymphoblasts. The hypomutability in FA cells was shown to be associated with an...

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PMID: 1685031
DOI: 10.1007/BF01233624

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