Molecular spectrum of mutations induced at the HPRT locus by a cross-linking agent in human cell lines with different repair capacities.

doi:10.1016/0921-8777(93)90025-c

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Article

Molecular spectrum of mutations induced at the HPRT locus by a cross-linking agent in human cell lines with different repair capacities.

Mutation research - 1 Aug 1993

Papadopoulo D, Laquerbe A, Guillouf C, Moustacchi E

Abstract excerpt

Molecular characterization of mutations photoinduced by a cross-linking agent, 4,5',8-trimethylpsoralen (Me3Pso), in normal human lymphoblasts was conducted in parallel with lymphoblasts derived from Fanconi anemia patients. Such cells have been previously described to be impaired in repair of ps...

Topics

Base Sequence
Cell Line
Cross-Linking Reagents
DNA
DNA Repair
Fanconi Anemia
Humans
Hypoxanthine Phosphoribosyltransferase
Lymphocytes
Molecular Sequence Data
Mutation
Trioxsalen
Ultraviolet Rays

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