Molecular mechanisms of mutagen hypersensitivity in adenine phosphoribosyl transferase-deficient Friend mouse erythroleukaemia cells.

Article

Molecular mechanisms of mutagen hypersensitivity in adenine phosphoribosyl transferase-deficient Friend mouse erythroleukaemia cells.

British journal of biomedical science - 1 Sept 1997

Yadollahi-Farsani M, McKenna P G, McKelvey-Martin V J

Abstract excerpt

Deficiency of the enzyme adenine phosphoribosyltransferase (APRT) has been associated with hypersensitivity to the mutagenic effects of ethyl methanesulphonate (EMS) and 254 nm ultraviolet (UV) radiation in clone 707 of Friend mouse erythroleukaemia (FEL) cells. The molecular nature of spontaneou...

Topics

Adenine Phosphoribosyltransferase
Animals
Friend murine leukemia virus
Leukemia, Erythroblastic, Acute
Mice
Mutation
Polymerase Chain Reaction
Tumor Cells, Cultured

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