The mutagenic processing of psoralen photolesions leaves a highly specific signature at an endogenous human locus.

doi:10.1006/jmbi.1995.0597

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Article

The mutagenic processing of psoralen photolesions leaves a highly specific signature at an endogenous human locus.

Journal of molecular biology - 17 Nov 1995

Laquerbe A, Guillouf C, Moustacchi E, Papadopoulo D

Abstract excerpt

To assess the role of a given genotoxic agent in the etiology of human cancers, it is useful to establish the mutational specificity of this agent. The aim of this study was to investigate whether the processing of psoralen photolesions, interstrand cross-links (CL) and monoadducts (MA), leaves a specific molecular signature in the mutational events produced at an endogenous locus, HPRT. Human lymphoblasts were...

Topics

Base Sequence
Cell Line
DNA Adducts
DNA Damage
Furocoumarins
Humans
Hypoxanthine Phosphoribosyltransferase
Lymphocytes
Male
Molecular Sequence Data
Mutagens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Photosensitizing Agents

Point Mutation

RNA, Messenger

Thymine

Trioxsalen

Ultraviolet Rays

Source

Open in PubMed

Identifiers

PMID: 7473757
DOI: 10.1006/jmbi.1995.0597

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7473757-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The mutagenic processing of psoralen photolesions leaves a highly specific signature at an endogenous human locus.PMID 7473757Read ↗

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