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Article

Reciprocal congenic lines for a major stroke QTL on rat chromosome 1.

Physiological genomics - 11 Oct 2006

Rubattu Speranza, Hubner Norbert, Ganten Ursula, Evangelista Anna, Stanzione Rosita, Di Angelantonio Emanuele, Plehm Ralph, Langanki Reika, Gianazza Elisabetta, Sironi Luigi, D'Amati Giulia, Volpe Massimo

Abstract excerpt

We previously identified a quantitative trait locus (QTL) for stroke proneness between the kallikrein (Klk) and Mt1pa markers on rat chromosome 1. To gain functional insights, we constructed congenic strains by introgressing either the whole or selected chromosomal segments from the stroke-prone (SHRsp) onto the stroke-resistant (SHRsr) spontaneously hypertensive rat genome and vice versa. The phenotype was the...

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PMID: 16835352
DOI: 10.1152/physiolgenomics.00086.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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