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Article

Two genomic regions of chromosomes 1 and 18 explain most of the stroke susceptibility under salt loading in stroke-prone spontaneously hypertensive rat/Izm.

Hypertension (Dallas, Tex. : 1979) - 1 Jul 2013

Gandolgor Tsend-Ayush, Ohara Hiroki, Cui Zong-Hu, Hirashima Tsukasa, Ogawa Toshiko, Saar Kathrin, Hübner Norbert, Watanabe Takeshi, Isomura Minoru, Nabika Toru

Abstract excerpt

To clarify the genetic mechanisms of stroke susceptibility in the stroke-prone spontaneously hypertensive rat (SHRSP), a quantitative trait locus (QTL) analysis was performed. Using 295 F2 rats of a cross between SHRSP/Izm and SHR/Izm, 2 major QTLs for stroke latency under salt loading were identified on chromosomes (chr) 1 and 18. Evaluation of 6 reciprocal single and double congenic rats for these QTLs showed...

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PMID: 23690346
DOI: 10.1161/HYPERTENSIONAHA.111.00488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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