Article
Genetic effects of blood pressure quantitative trait loci on hypertension-related organ damage: evaluation using multiple congenic strains.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Sept 2008
Ishikawa Noriyoshi, Harada Yuji, Maruyama Riruke, Masuda Junichi, Nabika Toru
Abstract excerpt
On rat chromosome 1, quantitative trait loci (QTLs) for susceptibility to hypertension-related renal diseases and cerebral stroke are identified in a cluster, some of which have been previously claimed to be independent of hypertension. In this study, we therefore attempted to excise genomic regions contributing to salt-induced renal damage and cerebral stroke using five congenic rats for blood pressure QTL on...
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