Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10.

doi:10.1073/pnas.92.19.8778

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Article

Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10.

Proceedings of the National Academy of Sciences of the United States of America - 12 Sept 1995

Kreutz R, Hübner N, James M R, Bihoreau M T, Gauguier D, Lathrop G M, Ganten D, Lindpaintner K

Abstract excerpt

We have previously identified a locus on rat chromosome 10 as carrying a major hypertension gene, BP/SP-1. The 100:1 odds support interval for this gene extended over a 35-centimorgan (cM) region of the chromosome that included the angiotensin I-converting enzyme (ACE) locus as demonstrated in a cross between the stroke-prone spontaneously hypertensive rat (SHRSPHD) and the normotensive Wistar-Kyoto (WKY-0HD)...

Topics

Animals
Base Sequence
Chromosome Mapping
Crosses, Genetic
Female
Genetic Linkage
Genetic Markers
Genotype
Hypertension
Male
Meiosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Phenotype

Rats

Rats, Inbred SHR

Rats, Inbred WKY

Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7568016
DOI: 10.1073/pnas.92.19.8778
PMCID: PMC41050

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7568016-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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