Article
Production of conditional point mutant knockin mice.
Genesis (New York, N.Y. : 2000) - 1 Jul 2006
Skvorak Kristen, Vissel Bryce, Homanics Gregg E
Abstract excerpt
Genetically engineered mice with point mutations in endogenous genes (i.e., knockin mice) are extremely useful tools for dissecting gene function. Currently available methodologies for creating knockin mice are limited in that the introduced mutation is globally present in all cells of the animal from conception through adulthood. In this report, we describe a strategy for creating mice in which a point mutant...
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