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Conditional Single Vector CRISPR/SaCas9 Viruses for Efficient Mutagenesis in the Adult Mouse Nervous System.

Cell reports - 24 Mar 2020

Hunker Avery C, Soden Marta E, Krayushkina Dasha, Heymann Gabriel, Awatramani Rajeshwar, Zweifel Larry S

Abstract excerpt

Mice engineered for conditional, cell type-specific gene inactivation have dominated the field of mouse genetics because of the high efficiency of Cre-loxP-mediated recombination. Recent advances in CRISPR/Cas9 technologies have provided alternatives for rapid gene mutagenesis for loss-of-function (LOF) analysis. Whether these strategies can be streamlined for rapid genetic analysis with the efficiencies...

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Identifiers

PMID: 32209486
DOI: 10.1016/j.celrep.2020.02.092
PMCID: PMC7212805

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