Article
Knock-in approaches.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011
Roebroek Anton J M, Gordts Philip L S M, Reekmans Sara
Abstract excerpt
Molecular genetic strategies to study gene function in mice or to generate a mouse model for a human disease are continuously under development. The application and importance of knock-in approaches are increasing. This chapter elaborates on novel developments for the generation of knock-in mice. Special emphasis is given to recombinase-mediated cassette exchange, a new emerging knock-in strategy that enables...
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