Article
When reverse genetics meets physiology: the use of site-specific recombinases in mice.
FEBS letters - 2 Oct 2002
Tronche François, Casanova Emilio, Turiault Marc, Sahly Iman, Kellendonk Christoph
Abstract excerpt
The use of site-specific recombinases enables the precise introduction of defined genetic mutations into the mouse genome. In theory, any deletion, point mutation, inversion or translocation can be modeled in mice. Because gene targeting is controlled both spatially and temporally, the function of a given gene can be studied in the desired cell types and at a specific time point. This 'genetic dissection' allows...
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