Article
Generation of an Lpar1-EGFP Fusion Knock-in Transgenic Mouse Line.
Cell biochemistry and biophysics - 1 Sept 2021
Rivera Richard, Williams Nyssa A, Kennedy Grace G, Sánchez-Pavón Paloma, Chun Jerold
Abstract excerpt
Lysophosphatidic acid (LPA) is a lysophospholipid that acts as an extracellular signal through the activation of cognate G protein-coupled receptors (GPCRs). There are six known LPA receptors (LPA1-6). The first such receptor, LPA1, was identified in the embryonic brain and has been studied extensively for gene expression throughout the body, including through studies of receptor-null mice. However, identifying...
Topics
- Animals
- Female
- Male
- Mice
- Alleles
- Central Nervous System
- Embryonic Stem Cells
- Gene Knock-In Techniques
- Green Fluorescent Proteins
- Mice, Transgenic
- Receptors, Lysophosphatidic Acid