Strategies to achieve conditional gene mutation in mice.

Abstract excerpt

The laboratory mouse is an ideal model organism for studying disease because it is physiologically similar to human and also because its genome is readily manipulated. Genetic engineering allows researchers to introduce specific loss-of-function or gain-of-function mutations into genes and then to study the resulting phenotypes in an in vivo context. One drawback of using traditional transgenic and knockout mice...

Topics

• Animals
• Animals, Genetically Modified
• Gene Expression Regulation
• Mice
• Mutation
• Recombination, Genetic