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Article

Generation and characterization of p53 mutant mice.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2003

Dumble Melissa L, Donehower Lawrence A, Lu Xiongbin

Abstract excerpt

p53 is one of the most well-characterized members of the tumor suppressor gene family. The role of p53 in controlling cellular homeostasis has proven critical, with over half of all human tumors having either lost or mutated p53. The emergence of technology facilitating the ablation of a gene within an animal's genome allowed great advances in the study of p53. The p53 knockout mouse was one of the first of its...

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PMID: 12824523
DOI: 10.1385/1-59259-408-5:29

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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