Article
Genetic knockouts in mice: an update.
Experientia - 15 Nov 1995
Shastry B S
Abstract excerpt
Gene disruption technology in mammals, by homologous recombination in embryonic stem cells, is a powerful method to manipulate the mouse germ line. In the past decade it has produced a wealth of knowledge concerning neuronal development, neurodegenerative disorders and the roles of oncogenes, Hox genes and growth factors during development. A surprising variety of genes, however, have given unexpected and...
Topics
- Animals
- Cloning, Molecular
- Embryo, Mammalian
- Exons
- Genetic Techniques
- Humans
- Kanamycin Kinase
- Mammals
- Mice
- Mice, Knockout
- Models, Genetic
- Phenotype
- Phosphotransferases (Alcohol Group Acceptor)