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Article

Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases.

Pharmacology & therapeutics - 1 Mar 2007

Gavériaux-Ruff Claire, Kieffer Brigitte L

Abstract excerpt

Conditional gene knockout represents an extremely powerful approach to study the function of single genes in the nervous system. The Cre-LoxP system is the most advanced technology for spatial and temporal control of genetic inactivation, and there is rapid progress using this methodology in neuroscience research. In this approach, mice with LoxP sites flanking the gene of interest (floxed mice) are bred with...

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Identifiers

PMID: 17289150
DOI: 10.1016/j.pharmthera.2006.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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