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Article

Genotoxic-activated G2-M checkpoint exit is dependent on CDC25B phosphatase expression

1 Jun 2006

Abstract excerpt

Cell cycle arrest at the G2-M checkpoint is an essential feature of the mechanisms that preserve genomic integrity. CDC25 phosphatases control cell cycle progression by dephosphorylating and activating cyclin-dependent kinase/cyclin complexes. Their activities are, therefore, tightly regulated to modulate cell cycle arrest in response to DNA damage exposure. Here, we report that overexpression of CDC25B affects...

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PMID: 16818502
DOI: 10.1158/1535-7163.mct-06-0099

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