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Article

CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage.

Cell cycle (Georgetown, Tex.) - 1 Sept 2005

Cazales Martine, Schmitt Estelle, Montembault Emilie, Dozier Christine, Prigent Claude, Ducommun Bernard

Abstract excerpt

CDC25B is one of the three human dual-specificity phosphatases involved in the activation of cyclin-dependent kinases at key stages of the cell division cycle. CDC25B that is responsible for the activation of CDK1-cyclin B1 is regulated by phosphorylation. The STK15/Aurora-A kinase locally phosphorylates CDC25B on serine 353 at the centrosome during the G2/M transition. Here we have investigated this...

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Source

Identifiers

PMID: 16082213
DOI: 10.4161/cc.4.9.1964

Genes

CDK1
UCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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