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Article

GADD45 induction of a G <sub>2</sub> /M cell cycle checkpoint

30 Mar 1999

Abstract excerpt

G1/S and G2/M cell cycle checkpoints maintain genomic stability in eukaryotes in response to genotoxic stress. We report here both genetic and functional evidence of a Gadd45-mediated G2/M checkpoint in human and murine cells. Increased expression of Gadd45 via microinjection of an expression vector into primary human fibroblasts arrests the cells at the G2/M boundary with a phenotype of MPM2 immunopositivity, 4n...

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PMID: 10097101
DOI: 10.1073/pnas.96.7.3706

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