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Article

Cell cycle checkpoint control mechanisms that can be disrupted in cancer.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2004

Dash Bipin C, El-Deiry Wafik S

Abstract excerpt

Maintenance of genomic integrity is essential to avoid cellular transformation, neoplasia, or cell death. DNA synthesis, mitosis, and cytokinesis are important cellular processes required for cell division and the maintenance of cellular homeostasis; they are governed by many extra- and intra-cellular stimuli. Progression of normal cell division depends on cyclin interaction with cyclin-dependent kinases (Cdk)...

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PMID: 15187251
DOI: 10.1385/1-59259-788-2:099

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