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Article

CDC25B induces cellular senescence and correlates with tumor suppression in a p53-dependent manner

1 Jan 2021

Abstract excerpt

The phosphatase cell division cycle 25B (Cdc25B) regulates cell cycle progression. Increased Cdc25B levels are often detected in cancer cell lines and human cancers and have been implicated in contributing to tumor growth, potentially by providing cancer cells with the ability to bypass checkpoint controls. However, the specific mechanism by which increased Cdc25B impacts tumor progression is not clear. Here we...

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PMID: 33745968
DOI: 10.1016/j.jbc.2021.100564

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