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Article

Cell cycle control, checkpoint mechanisms, and genotoxic stress.

1 Feb 1999

Abstract excerpt

The ability of cells to maintain genomic integrity is vital for cell survival and proliferation. Lack of fidelity in DNA replication and maintenance can result in deleterious mutations leading to cell death or, in multicellular organisms, cancer. The purpose of this review is to discuss the known signal transduction pathways that regulate cell cycle progression and the mechanisms cells employ to insure DNA...

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Identifiers

PMID: 10229703
DOI: 10.1289/ehp.99107s15

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