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Article

Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response.

Genetics - 1 Sept 2006

Benedetti Cristina, Haynes Cole M, Yang Yun, Harding Heather P, Ron David

Abstract excerpt

Perturbation of the protein-folding environment in the mitochondrial matrix selectively upregulates the expression of nuclear genes encoding mitochondrial chaperones. To identify components of the signal transduction pathway(s) mediating this mitochondrial unfolded protein response (UPR(mt)), we first isolated a temperature-sensitive mutation (zc32) that conditionally activates the UPR(mt) in C. elegans and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16816413
DOI: 10.1534/genetics.106.061580
PMCID: PMC1569816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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