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Article

The myosin chaperone UNC-45 has an important role in maintaining the structure and function of muscle sarcomeres during adult aging.

Molecular biology of the cell - 1 Jul 2024

Matheny Courtney J, Qadota Hiroshi, Bailey Aaron O, Valdebenito-Silva Silvana, Oberhauser Andres F, Benian Guy M

Abstract excerpt

C. elegans undergo age-dependent declines in muscle organization and function, similar to human sarcopenia. The chaperone UNC-45 is required to fold myosin heads after translation and is likely used for refolding after thermally- or chemically-induced unfolding. UNC-45's TPR region binds HSP-90 and its UCS domain binds myosin heads. We observe early onset sarcopenia when UNC-45 is reduced at the beginning of...

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Identifiers

PMID: 38809582
DOI: 10.1091/mbc.E23-12-0488
PMCID: PMC11244168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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