Article
Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions.
Journal of visualized experiments : JoVE - 7 Jun 2020
Dror Shiran, Meidan Tomer D, Karady Ido, Ben-Zvi Anat
Abstract excerpt
Correct folding and assembly of proteins and protein complexes are essential for cellular function. Cells employ quality control pathways that correct, sequester or eliminate damaged proteins to maintain a healthy proteome, thus ensuring cellular proteostasis and preventing further protein damage. Because of redundant functions within the proteostasis network, screening for detectable phenotypes using knockdown...
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