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Challenging muscle homeostasis uncovers novel chaperone interactions in Caenorhabditis elegans

6 Nov 2014

Abstract excerpt

Proteome stability is central to cellular function and the lifespan of an organism. This is apparent in muscle cells, where incorrect folding and assembly of the sarcomere contributes to disease and aging. Apart from the myosin-assembly factor UNC-45, the complete network of chaperones involved in assembly and maintenance of muscle tissue is currently unknown. To identify additional factors required for sarcomere...

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PMID: 25988162
DOI: 10.3389/fmolb.2014.00021

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Challenging muscle homeostasis uncovers novel chaperone interactions in Caenorhabditis elegansPMID 25988162Read ↗

The myosin chaperone UNC-45 has an important role in maintaining the structure and function of muscle sarcomeres during adult aging.Semantic proximity Read ↗

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The myosin-binding UCS domain but not the Hsp90-binding TPR domain of the UNC-45 chaperone is essential for function in Caenorhabditis elegans.Semantic proximity Read ↗

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