Article
Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans.
Cell - 6 Aug 2004
Hoppe Thorsten, Cassata Giuseppe, Barral José M, Springer Wolfdieter, Hutagalung Alex H, Epstein Henry F, Baumeister Ralf
Abstract excerpt
The organization of the motor protein myosin into motile cellular structures requires precise temporal and spatial control. Caenorhabditis elegans UNC-45 facilitates this by functioning both as a chaperone and as a Hsp90 cochaperone for myosin during thick filament assembly. Consequently, mutations in C. elegans unc-45 result in paralyzed animals with severe myofibril disorganization in striated body wall...
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