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Article

ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.

Developmental cell - 1 Oct 2007

Haynes Cole M, Petrova Kseniya, Benedetti Cristina, Yang Yun, Ron David

Abstract excerpt

The cellular response to unfolded and misfolded proteins in the mitochondrial matrix is poorly understood. Here, we report on a genome-wide RNAi-based screen for genes that signal the mitochondrial unfolded protein response (UPR(mt)) in C. elegans. Unfolded protein stress in the mitochondria correlates with complex formation between a homeodomain-containing transcription factor DVE-1 and the small ubiquitin-like...

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Identifiers

PMID: 17925224
DOI: 10.1016/j.devcel.2007.07.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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