Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans.

Genetics - 1 Apr 2011

Segref Alexandra, Torres Serena, Hoppe Thorsten

Abstract excerpt

In eukaryotic cells, the ubiquitin/proteasome system (UPS) is a key determinant of proteostasis as it regulates the turnover of damaged proteins. However, it is still unclear how the UPS integrates intrinsic and environmental challenges to promote organismal development and survival. Here, we set up an in vivo degradation assay to facilitate the genetic identification of ubiquitin-dependent proteolysis pathways...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Gene Regulatory Networks
Share to Genes, Helminth

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Helminth

Share to Immunoblotting

Share to Proteasome Endopeptidase Complex

Share to Protein Folding

Share to Ubiquitin

Source

Open in PubMed Open full text

Identifiers

PMID: 21288877
DOI: 10.1534/genetics.111.126797
PMCID: PMC3070531

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans.PMID 21288877Read ↗

PRO-FitS: a novel phenotypic assay to identify enhancers of proteostasis in <i>C. elegans</i>Semantic proximity Read ↗

Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway.Semantic proximity Read ↗

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions.Semantic proximity Read ↗

Hijacking Cellular Stress Responses to Promote LifespanSemantic proximity Read ↗

Hyperactivation of the proteasome core particle in Caenorhabditis elegans protects against proteotoxic stress and extends lifespanSemantic proximity Read ↗

Hyperactive 20S Proteasome Enhances Proteostasis and ERAD in <i>C. elegans</i> via degradation of Intrinsically Disordered ProteinsSemantic proximity Read ↗

Proteostasis and longevity: when does aging really begin?Semantic proximity Read ↗

Proteostasis and longevity: when does aging really begin?Semantic proximity Read ↗

Immunohistochemical analysis reveals variations in proteasome tissue expression in C. elegans.Semantic proximity Read ↗

E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development.Semantic proximity Read ↗

ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.Semantic proximity Read ↗

Widespread Proteome Remodeling and Aggregation in Aging C. elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.