Article
The amino-terminal 14 amino acids of v-src can functionally replace the extracellular and transmembrane domains of v-erbB.
Molecular and cellular biology - 1 Sept 1991
McMahon M, Schatzman R C, Bishop J M
Abstract excerpt
The retroviral oncogene v-erbB encodes a truncated form of the receptor for epidermal growth factor, an integral membrane protein-tyrosine kinase. By contrast, the oncogene v-src encodes a protein-tyrosine kinase that is a peripheral membrane protein. The morphologies and spectra of cells transfo...
Topics
- Alleles
- Animals
- Blotting, Western
- Cell Fractionation
- Cell Line
- Cell Transformation, Neoplastic
- Cells, Cultured
- Membrane Proteins
- Mice
- Oncogene Protein pp60(v-src)
- Oncogene Proteins v-erbB
- Rats
- Recombinant Fusion Proteins
- Retroviridae Proteins, Oncogenic