Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation.

doi:10.1128/mcb.10.6.3048-3055.1990

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Article

Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation.

Molecular and cellular biology - 1 Jun 1990

Massoglia S, Gray A, Dull T J, Munemitsu S, Kun H J, Schlessinger J, Ullrich A

Abstract excerpt

The transforming gene product of avian erythroblastosis virus, v-erbB, is derived from the epidermal growth factor (EGF) receptor but has lost its extracellular ligand-binding domain and was mutated in its cytoplasmic portion, which is thought to be responsible for biological signal generation. We have repaired the deletion of extracellular EGF-binding sequences and investigated the functional consequences of...

Topics

Alpharetrovirus
Animals
Avian Leukosis Virus
Cell Division
Cell Transformation, Neoplastic
Cells, Cultured
Chimera
Cytoplasm
ErbB Receptors
Ligands
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oncogene Proteins v-erbB

Oncogene Proteins, Viral

Phosphorylation

Plasmids

Restriction Mapping

Retroviridae Proteins, Oncogenic

Source

Open in PubMed Open full text

Identifiers

PMID: 1971419
DOI: 10.1128/mcb.10.6.3048-3055.1990
PMCID: PMC360669

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1971419-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation.PMID 1971419Read ↗

Ligand-independent oncogenic signaling by the epidermal growth factor receptor: v-ErbB as a paradigm.Semantic proximity Read ↗

Role of EGF Receptor Regulatory Networks in the Host Response to Viral InfectionsSemantic proximity Read ↗

Tissue-specific transformation by oncogenic mutants of epidermal growth factor receptor.Semantic proximity Read ↗

Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants.Semantic proximity Read ↗

Cytoplasmic domain phosphorylation of heparin-binding EGF-like growth factor.Semantic proximity Read ↗

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Regulation of EGF receptor expression and function.Semantic proximity Read ↗

Cell transformation by the epidermal growth factor receptor and v-erbB.Semantic proximity Read ↗

A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling.Semantic proximity Read ↗

Mutational analysis of the role of the carboxy-terminal region of the v-erbB protein in erythroid cell transformation.Semantic proximity Read ↗

Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity.Semantic proximity Read ↗

Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins.Semantic proximity Read ↗

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