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Article

Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation.

Molecular and cellular biology - 1 Jun 1990

Massoglia S, Gray A, Dull T J, Munemitsu S, Kun H J, Schlessinger J, Ullrich A

Abstract excerpt

The transforming gene product of avian erythroblastosis virus, v-erbB, is derived from the epidermal growth factor (EGF) receptor but has lost its extracellular ligand-binding domain and was mutated in its cytoplasmic portion, which is thought to be responsible for biological signal generation. We have repaired the deletion of extracellular EGF-binding sequences and investigated the functional consequences of...

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Source

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Identifiers

PMID: 1971419
DOI: 10.1128/mcb.10.6.3048-3055.1990
PMCID: PMC360669

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation.PMID 1971419Read ↗

Ligand-independent oncogenic signaling by the epidermal growth factor receptor: v-ErbB as a paradigm.Semantic proximity Read ↗

Role of EGF Receptor Regulatory Networks in the Host Response to Viral InfectionsSemantic proximity Read ↗

Tissue-specific transformation by oncogenic mutants of epidermal growth factor receptor.Semantic proximity Read ↗

Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants.Semantic proximity Read ↗

Cytoplasmic domain phosphorylation of heparin-binding EGF-like growth factor.Semantic proximity Read ↗

Cell and molecular biology of epidermal growth factor receptor.Semantic proximity Read ↗

Regulation of EGF receptor expression and function.Semantic proximity Read ↗

Cell transformation by the epidermal growth factor receptor and v-erbB.Semantic proximity Read ↗

A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling.Semantic proximity Read ↗

Mutational analysis of the role of the carboxy-terminal region of the v-erbB protein in erythroid cell transformation.Semantic proximity Read ↗

Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity.Semantic proximity Read ↗

Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins.Semantic proximity Read ↗

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