Mutations in the SH3 domain of the src oncogene which decrease association of phosphatidylinositol 3'-kinase activity with pp60v-src and alter cellular morphology.

Abstract excerpt

To analyze the signaling pathways utilized in malignant transformation by pp60v-src, we have isolated and characterized src mutants which possess normal levels of protein tyrosine kinase activity but which cause only a partially transformed phenotype. Our hypothesis is that such mutants are partially defective for transformation because they are defective in their ability to activate specific components of the...

Topics

• 1-Phosphatidylinositol 4-Kinase
• Animals
• Cells, Cultured
• Chick Embryo
• Fibroblasts
• Glycine
• Mutation
• Myristic Acids
• Oncogene Protein pp60(v-src)
• Oncogenes
• Phosphotransferases