Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell transformation by the epidermal growth factor receptor and v-erbB.

Cancer cells (Cold Spring Harbor, N.Y. : 1989) - 1 Aug 1991

Hayman M J, Enrietto P J

Abstract excerpt

It has become increasingly apparent that growth factor receptors can function as oncogenic proteins and play causal roles in cell transformation. A prime example is the epidermal growth factor receptor (EGFR), which belongs to the ligand-activated tyrosine kinase receptor family and is overexpressed in certain human tumors. The transforming gene of avian erythroblastosis virus, v-erbB, encodes a truncated form of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to ErbB Receptors
Share to EGFR gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Oncogenes

Share to Promoter Regions, Genetic

Share to Retroviridae Proteins, Oncogenic

Share to Transduction, Genetic

Source

Identifiers

PMID: 1681843

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell transformation by the epidermal growth factor receptor and v-erbB.PMID 1681843Read ↗

Ligand-independent oncogenic signaling by the epidermal growth factor receptor: v-ErbB as a paradigm.Semantic proximity Read ↗

Tissue-specific transformation by oncogenic mutants of epidermal growth factor receptor.Semantic proximity Read ↗

Mechanisms for oncogenic activation of the epidermal growth factor receptor.Semantic proximity Read ↗

Mutational analysis of the role of the carboxy-terminal region of the v-erbB protein in erythroid cell transformation.Semantic proximity Read ↗

Role of EGF Receptor Regulatory Networks in the Host Response to Viral InfectionsSemantic proximity Read ↗

Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation.Semantic proximity Read ↗

Signaling through the epidermal growth factor receptor during the development of malignancy.Semantic proximity Read ↗

Epidermal growth factor receptor (EGFR) signaling in cancer.Semantic proximity Read ↗

[Mutations in the epidermal growth factor receptor: structure and biological function in human tumors].Semantic proximity Read ↗

Oncogenic genes and human malignancy.Semantic proximity Read ↗

The EGF/ErbB Receptor Family and ApoptosisSemantic proximity Read ↗

Resistance to transformation by insertionally activated c-erbB is a dominant phenotype in fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.