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Article

Functional dissection of transformation by c‐Src and v‐Src

21 Dec 2007

Abstract excerpt

The c-src proto-oncogene product, c-Src, is frequently over-expressed and activated in various human malignant cancers, implicating a role for c-Src in cancer progression. To verify the role of c-Src, we analyzed the transforming ability of c-Src in mouse embryonic fibroblasts that lack Csk, a negative regulator of Src family kinases. Although Csk deficiency is not sufficient for cell transformation, c-Src...

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Identifiers

PMID: 18173743
DOI: 10.1111/j.1365-2443.2007.01145.x

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