Article
Mutational analysis of the role of the carboxy-terminal region of the v-erbB protein in erythroid cell transformation.
Oncogene - 1 May 1993
Lee E B, Beug H, Hayman M J
Abstract excerpt
The v-erbB protein encoded by the avian erythroblastosis virus AEV-H is responsible for the transformation of fibroblasts and erythroblasts by this virus. Deletion of amino acids 961-1102, which lie carboxy terminal to the kinase domain of the v-erbB protein, destroys the ability of the virus to transform erythroid cells without severely affecting fibroblast transformation. This region is termed the E-domain and...
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