Mutational analysis of the role of the carboxy-terminal region of the v-erbB protein in erythroid cell transformation.

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Article

Mutational analysis of the role of the carboxy-terminal region of the v-erbB protein in erythroid cell transformation.

Oncogene - 1 May 1993

Lee E B, Beug H, Hayman M J

Abstract excerpt

The v-erbB protein encoded by the avian erythroblastosis virus AEV-H is responsible for the transformation of fibroblasts and erythroblasts by this virus. Deletion of amino acids 961-1102, which lie carboxy terminal to the kinase domain of the v-erbB protein, destroys the ability of the virus to...

Topics

Amino Acid Sequence
Animals
Cell Transformation, Neoplastic
Chick Embryo
Erythroblasts
Molecular Sequence Data
Mutation
Oncogene Proteins v-erbB
Oncogene Proteins, Viral
Phosphorylation
Rabbits
Retroviridae Proteins, Oncogenic
Structure-Activity Relationship
Tyrosine

Source

Open in PubMed

Identifiers

PMID: 8097581

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8097581-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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