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Article

Functions of the v-Src protein tyrosine kinase.

Cell biology international - 1 May 1994

Fincham V, Frame M, Haefner B, Unlu M, Wyke A, Wyke J

Abstract excerpt

The peripheral non-receptor tyrosine kinase oncoprotein, v-Src, has pleiotropic effects. It is a mitogen for quiescent cells, substituting for both competence and progression factor-mediated signals but it also induces cellular morphological transformation. We are dissecting the activities of v-Src by studying mutant proteins, including those with temperature sensitive (ts) effects, in different cellular...

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Identifiers

PMID: 8049678
DOI: 10.1006/cbir.1994.1083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Functions of the v-Src protein tyrosine kinase.PMID 8049678Read ↗

Mitogenesis by v-Src: fluctuations throughout G1 of classical immediate early AP-1 and mitogen-activated protein kinase responses that parallel the need for the oncoprotein.Semantic proximity Read ↗

Role of Gas1 down-regulation in mitogenic stimulation of quiescent NIH3T3 cells by v-Src.Semantic proximity Read ↗

Mutations in v-Src SH3 and catalytic domains that jointly confer temperature-sensitive transformation with minimal temperature-dependent changes in cellular tyrosine phosphorylation.Semantic proximity Read ↗

Functional dissection of transformation by c‐Src and v‐SrcSemantic proximity Read ↗

Mitogenesis of quiescent chick fibroblasts by v-Src: dependence on events at the membrane leading to early changes in AP-1.Semantic proximity Read ↗

Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition.Semantic proximity Read ↗

Annexin 2 has a dual role as regulator and effector of v-Src in cell transformation.Semantic proximity Read ↗

Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src.Semantic proximity Read ↗

v-src-induced cell shape changes in rat fibroblasts require new gene transcription and precede loss of focal adhesions.Semantic proximity Read ↗

Slow time-dependent cellular transformation induced at restrictive temperature by ts-src mutants.Semantic proximity Read ↗

MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway.Semantic proximity Read ↗

The amino-terminal 14 amino acids of v-src can functionally replace the extracellular and transmembrane domains of v-erbB.Semantic proximity Read ↗

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