Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity.

doi:10.1006/excr.2002.5494

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Article

Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity.

Experimental cell research - 15 Apr 2002

Danielsen Andrew J, Maihle Nita J

Abstract excerpt

The retroviral oncogene S3-v-erbB is a transduced, truncated form of the avian EGF (ErbB-1) receptor. Infection of avian fibroblasts with a retroviral vector expressing S3-v-ErbB results in ligand-independent cell transformation, which is accompanied by the assembly of a transformation-specific phosphoprotein signaling complex and anchorage-independent cell growth. It previously had been reported, using...

Topics

Alanine
Animals
Aspartic Acid
Catalysis
Cell Line, Transformed
Cell Nucleus
Cell Transformation, Neoplastic
Chick Embryo
ErbB Receptors
Fibroblasts
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ligands

Mutation

Oncogene Proteins v-erbB

Protein Kinases

Protein Structure, Tertiary

Signal Transduction

Tyrosine

Source

Open in PubMed

Identifiers

PMID: 11925101
DOI: 10.1006/excr.2002.5494

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