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Article

Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity.

Experimental cell research - 15 Apr 2002

Danielsen Andrew J, Maihle Nita J

Abstract excerpt

The retroviral oncogene S3-v-erbB is a transduced, truncated form of the avian EGF (ErbB-1) receptor. Infection of avian fibroblasts with a retroviral vector expressing S3-v-ErbB results in ligand-independent cell transformation, which is accompanied by the assembly of a transformation-specific phosphoprotein signaling complex and anchorage-independent cell growth. It previously had been reported, using...

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Identifiers

PMID: 11925101
DOI: 10.1006/excr.2002.5494

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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