Ligand-independent oncogenic signaling by the epidermal growth factor receptor: v-ErbB as a paradigm.

Abstract excerpt

Relay of information from the extracellular environment into the cell often results from a peptide growth factor binding to its cognate cell surface receptor; this event is an integral mechanism by which many cellular functions occur, including cell growth, motility, and survival. In recent years, however, this requirement for ligand binding has been shown to be surpassed by several distinct mechanisms, including...

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