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Article

c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential.

Molecular and cellular biology - 1 Nov 2009

Marcotte Richard, Zhou Lixin, Kim Harold, Roskelly Calvin D, Muller William J

Abstract excerpt

Previous studies have demonstrated that c-Src tyrosine kinase interacts specifically with ErbB2, but not with other members of the epidermal growth factor receptor (EGFR) family. To identify the site of interaction, we recently used a chimeric EGFR/ErbB2 receptor approach to show that c-Src requires the kinase region of ErbB2 for binding. Here, we demonstrate that retention of a conserved amino acid motif...

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Source

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Identifiers

PMID: 19704002
DOI: 10.1128/MCB.01731-08
PMCID: PMC2772728

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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