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Article

Tolerance for ATP-insensitive K(ATP) channels in transgenic mice.

Circulation research - 23 Nov 2001

Koster J C, Knopp A, Flagg T P, Markova K P, Sha Q, Enkvetchakul D, Betsuyaku T, Yamada K A, Nichols C G

Abstract excerpt

To examine the role of sarcolemmal K(ATP) channels in cardiac function, we generated transgenic mice expressing GFP-tagged Kir6.2 subunits with reduced ATP sensitivity under control of the cardiac alpha-myosin heavy chain promoter. Four founder mice were isolated, and both founders and progeny were all apparently normal and fertile. Electrocardiograms from conscious animals also appeared normal, although mean...

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Identifiers

PMID: 11717159
DOI: 10.1161/hh2301.100342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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