Article
Targeted expression of a dominant-negative K(v)4.2 K(+) channel subunit in the mouse heart.
Circulation research - 26 Nov 1999
Wickenden A D, Lee P, Sah R, Huang Q, Fishman G I, Backx P H
Abstract excerpt
Action potential duration is prolonged in many forms of heart disease, often as a result of reductions in Ca(2+)-independent transient outward K(+) currents (ie, I(to)). To examine the effects of a primary reduction in I(to) current in the heart, transgenic mice were generated that express a dominant-negative N-terminal fragment of the K(v)4.2 pore-forming potassium channel subunit under the control of the mouse...
Topics
- Action Potentials
- Animals
- Cardiomegaly
- Echocardiography
- Electrocardiography
- Genes, Dominant
- Heart Failure
- Hemodynamics
- Ion Transport
- Mice
- Mice, Inbred CBA
- Mice, Transgenic
- Myocardial Contraction
- Myocardium
- Myosin Heavy Chains