Article
Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload.
Circulation research - 24 Oct 2008
Hu Xinli, Xu Xin, Huang Yimin, Fassett John, Flagg Thomas P, Zhang Ying, Nichols Colin G, Bache Robert J, Chen Yingjie
Abstract excerpt
Sarcolemmal ATP-sensitive potassium channels (K(ATP)) act as metabolic sensors that facilitate adaptation of the left ventricle to changes in energy requirements. This study examined the mechanism by which K(ATP) dysfunction impairs the left ventricular response to stress using transgenic mouse strains with cardiac-specific disruption of K(ATP) activity (SUR1-tg mice) or Kir6.2 gene deficiency (Kir6.2 KO). Both...
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