Article
Mice lacking sulfonylurea receptor 2 (SUR2) ATP-sensitive potassium channels are resistant to acute cardiovascular stress.
Journal of molecular and cellular cardiology - 1 Oct 2007
Stoller Douglas, Kakkar Rahul, Smelley Matthew, Chalupsky Karel, Earley Judy U, Shi Nian-Qing, Makielski Jonathan C, McNally Elizabeth M
Abstract excerpt
Adenosine triphosphate-sensitive potassium (K(ATP)) channels are thought to mediate the stress response by sensing intracellular ATP concentration. Cardiomyocyte K(ATP) channels are composed of the pore-forming Kir6.2 subunit and the regulatory sulfonylurea receptor 2 (SUR2). We studied the respo...
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