Article
CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis.
Physiological genomics - 1 Feb 2012
Neckář Jan, Šilhavy Jan, Zídek Václav, Landa Vladimír, Mlejnek Petr, Šimáková Miroslava, Seidman J G, Seidman Christine, Kazdová Ludmila, Klevstig Martina, Novák František, Vecka Marek, Papoušek František, Houštěk Josef, Drahota Zdeněk, Kurtz Theodore W, Kolář František, Pravenec Michal
Abstract excerpt
CD36 fatty acid translocase plays a key role in supplying heart with its major energy substrate, long-chain fatty acids (FA). Previously, we found that the spontaneously hypertensive rat (SHR) harbors a deletion variant of Cd36 gene that results in reduced transport of long-chain FA into cardiomyocytes and predisposes the SHR to cardiac hypertrophy. In the current study, we analyzed the effects of mutant Cd36 on...
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