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Article

Physiological and pathophysiological roles of ATP-sensitive K+ channels.

Progress in biophysics and molecular biology - 1 Feb 2003

Seino Susumu, Miki Takashi

Abstract excerpt

ATP-sensitive potassium (K(ATP)) channels are present in many tissues, including pancreatic islet cells, heart, skeletal muscle, vascular smooth muscle, and brain, in which they couple the cell metabolic state to its membrane potential, playing a crucial role in various cellular functions. The K(ATP) channel is a hetero-octamer comprising two subunits: the pore-forming subunit Kir6.x (Kir6.1 or Kir6.2) and the...

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PMID: 12565699
DOI: 10.1016/s0079-6107(02)00053-6

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